The Astor Place Riot occurred on May 10, 1849, at the now-demolished Astor Opera House in Manhattan and left between 22 and 31 rioters dead, and more than 120 people were injured. It was the deadliest to that date of a number of civic disturbances in Manhattan, which generally pitted immigrants and nativists against each other, or together against the wealthy who controlled the city's police and the state militia.

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https://en.wikipedia.org/wiki/Astor_Place_Riot

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